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Clostridium difficile (C diff) 

Clostridium difficile (klos-TRID-e-um dif-uh-SEEL), often called C. difficile or C. diff, is a bacterium that can cause symptoms ranging from diarrhea to life-threatening inflammation of the colon.

Illness from C. difficile can affect anyone in  a hospital or in long-term care facilities and typically occurs after use of antibiotic medications. However, studies show increasing rates of C. difficile infection among people traditionally not considered high risk, such as younger and healthy individuals without a history of antibiotic use or exposure to health care facilities.  C. diff kills about 250 people everyday in the US. The CDC has issued warnings about C. diff.  C. diff is becoming resistant to the antibiotics used to treat it.

Each year in the United States, about a half million people get sick from C. difficile, and in recent years, C. difficile infections have become more frequent, severe and difficult to treat. C. diff infection can be recurrent with each episode become more dangerous.  

Saccharomyces Boulardii has been used in Europe for 25 years to treat C. diff.  It is safe and effective as well as being good for you.  Saccharomyces Boulardii improves the immune system when used over time.  Saccharomyces Boulardii is effective in preventing the recurrence of C. diff infection.  Recurrent C. diff infections are more likely to be fatal. 

Recent double blind study...........

Practice Implications: Clostridium difficile is a Gram-positive bacterium that is a common cause of antibiotic-associated diarrhea and pseudomembranous colitis. C. difficile infection usually manifests as mild-to-moderate diarrhea, but severe colitis culminating in colectomy or death may also occur. Since around the year 2000, there has been a marked increase in the incidence of C. difficile infection. Increases in disease severity and mortality rates have also been observed, apparently because of the emergence of a more virulent strain of the organism. Treatment with vancomycin or metronidazole is usually effective, but the infection recurs in approximately 20% of patients after treatment with these antibiotics. Several double-blind trials have found that administration of various probiotic organisms can prevent the development or reduce the recurrence rate of C. difficile infection. The present study demonstrates that probiotics can also be used as an adjunct to antibiotic therapy to accelerate recovery from C. difficile-associated diarrhea.


Gaby AR. Clostridium difficile. In Gaby AR. Nutritional Medicine, Second Edition. Concord, NH, 2017, www.doctorgaby.com; chapter 310.

Saccharomyces Boulardii is also very effective for most IBS patients.

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