Vitamin B12 lozenges are a great tasting, high dose vitamin B12 product. Each berry flavored lozenge contains 5000 mcg methylcobalamin, a naturally occurring, highly bioavailable form of vitamin B12. They are designed to deliver B12 through the mucous membranes in order to bypass the need for intrinsic factor, a protein produced in the stomach that is necessary for maximal GI absorption of B12. Vitamin B12 in supplement form also reduces the need for stomach acid, which is typically required to separate food-derived B12 from food proteins.
It is important to let the lozenge dissolve slowly and not chew it in order to allow the vitamin to be absorbed properly through the mucosal tissue that lines mouth.
The methylcobalamin form of B12 converts to the metabolic intermediate cobalamin, which is converted to the two intracellular active forms of B12: methylcobalamin (for methylation cycles) and adenosylcobalamin (for mitochondrial metabolism of various energy sources: amino acids, odd chain fatty acids and cholesterol).
Methylation reactions are critical biochemical processes that assure proper cell differentiation and replication, the proper production of brain chemicals (neurotransmitters), methylation of DNA (epigenetic control of genetic expression), and methylation of certain hormones and neurotransmitters for their proper inactivation.
It is important to note that the methyl group contained in this dietary form is not utilized in methylation reactions. The sources of intracellular methyl groups are: methylfolate, SAMe, betaine, choline and methionine.
These lozenges provide 5000 mcg of B12, which is a dose a high enough to push absorption by mass action through the cellular diffusion pathway, typically estimated at 1%. They are an ideal way to help increase levels of B12 quickly, when higher doses of this vitamin are desired.
In cases where there are suspected genetic polymorphisms of B12 absorption and metabolism pathways, Designs for Health offers Trifolamin™ lozenges, which provides three forms of bioavailable B12 and additional methylfolate.
B12 Lozenges provide nutritional support for:
**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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